PRODUCTS

Generic Name: Metoprolol Tartrate
50 mg Film-Coated Tablet
BETA ADRENOCEPTOR BLOCKER

FORMULATION:
Each film-coated tablet contains:
Metoprolol Tartrate, USP……….. 50 mg

INDICATIONS:

For the treatment of hypertension, angina pectoris, cardiac arrhythmia, myocardial infarction and heart failure. It is also used in the management of hyperthyroidism and migraine.

DOSAGE & ROUTE OF ADMINISTRATION:

Adult dose:

For Hypertension:

Oral: Initial dose of 2 tablets daily, increased weekly according to the response of the patient to 8 tablets; can be taken twice daily or as prescribed by the physician. Usual maintenance dose is 2 to 4 tablets daily taken with or immediately following a meal or as prescribed by the physician.

For Angina Pectoris:

Oral: 50 mg Tablet: 1 to 2 tablets, 2 or 3 times daily in divided doses or as prescribed by the physician.

For Cardiac Arrhythmias:

Oral: 50 mg Tablet: 1 tablet to be taken 2 or 3 times daily, increased if necessary to 6 tablets daily in divided doses or as prescribed by the physician.

CONTRAINDICATIONS:

Sinus bradycardia; second and third degree A-V block; right ventricular failure secondary to pulmonary hypertension; congestive heart failure and cardiogenic shock.

PRECAUTIONS: Special Precaution

Metoprolol should not be given to patients with bronchospasm or asthma or to those with history of obstructive airway disease.

ADVERSE EFFECTS: Adverse Reaction

Metoprolol is well tolerated, and the adverse effects are generally mild and reversible. The most commonly reported adverse reactions during treatment is fatigue. Gangrene( in patients with severe peripheral circulatory disorder),throm- bocytopenia and agranulocytosis may occur very rarely(less than 1 case per 10,000 patients). The following adverse effects have been reported during the course of clinical studies or have been reported after routine use. Frequency estimates: very common, common, uncommon, rare to very rare.

DRUG INTERACTIONS:

• Interaction:

IV Ca-antagonist of verapamil and diltiazem type. Class I antiarrhythmics, antihistamines, H2 blockers, antidepressants, antipsychotics. Sympathomimetic ganglion-blocking agent, other B-blockers. MAOIS, clonidine, inhalation anesthetics, rifampicin, alcohol, hydralazine, indomethacin and other prostaglandin synthetase inhibitor. Oral antidiabetics. Digitalis glycosides.

AVAILABILITY:

Packaging/Presentation

Alu/Clear PVDC Blister Pack x 10’s (Box of 100’s)

For more information, please see full product information.