Ketoanalogues + Essential Amino Acids
KADNEY
Regulatory Class: Rx
Generic Name: Ketoanalogues + Essential Amino Acids
Formulation/s: Ca-4-methyl-2-oxo-valerate (α-ketoanalogue to leucine, Ca salt) 101 mg, Ca-3-methyl-2-oxo-butyrate (α-ketoanalogue to valine, Ca salt) 86 mg, Ca-2-oxo-3-phenylpropionate (α-ketoanalogue to phenylalanine, Ca salt) 68 mg, Ca-3-methyl-2-oxo-valerate (α-ketoanalogue to isoleucine, Ca salt) 67 mg, Ca-DL-2-hydroxy-4-(methylthio) butyrate (α-hydroxyanalogue to methionine, Ca salt) 59 mg, L-lysine acetate 105 mg, L-threonine 53 mg, L-histidine 38 mg, L-tyrosine 30 mg, L-tryptophan 23 mg. Total nitrogen content/tab: 36 mg, Ca/tab: 1.25 mmol equivalent to 0.05 g.
Indications or Use: Prevention & therapy of damage due to faulty or deficient protein metabolism in chronic renal insufficiency in connection w/ limited protein in food (≤40 g/day), usually in patients w/ Glomerular filtration rate <25 mL/min.
Dosage and Directions for Use: Adult (70 kg) 4-8 tab thrice a day. Duration: As long as Glomerular filtration rate <25 mL/min & concomitantly, dietary protein is restricted to ≤40 g daily.
Administration: Take with meals. Do not chew.
Contraindication: Hypersensitivity, hypercalcemia & disturbed amino acid metabolism.
Special Precaution: No experience in pregnancy & lactation.
Adverse Reaction: Metabolism and nutrition disorders: Very rare: hypercalcaemia. If hypercalcaemia occurs, the intake of vitamin D should be reduced. In case of persisting hypercalcaemia, the dose of the product as well as the intake of any other calcium sources has to be reduced.
Interactions: May cause or aggravate elevated serum Calcium levels w/ Calcium-containing drugs. Take drugs that form hard soluble compound w/ Calcium e.g., tetracyclines, quinolones (e.g., ciprofloxacin & norfloxacin), drugs containing Iron, fluoride or estramustine) w/ interval of at least 2 hours. Increased risk of arrhythmia w/ cardioactive glycosides if there are elevated serum Calcium levels during therapy. Reduce dose of Aluminum hydroxide administration, due to improved uremic symptoms during therapy.
Presentation/ Packaging: Film-coated tablet 100’s.
For more information, please see full product information.
